.png)
Fluorescence Quenching of Dendrimer-Encapsulated CdS...
Tailoring chemically converted graphenes using a wate...
댓글 쓰기 권한이 없습니다. 로그인 하시겠습니까?
Toehold-mediated DNA displacement-based surface-enhanced Raman scattering DNA sensor utilizing an Au?Ag bimetallic nanodendrite substrate
| Journal | Analytica Chimica Acta |
|---|---|
| Author | Saetbyeol Kima , Tran Ngoc Huana , Joohoon Kimb , So Young Yoo, Hoeil Chung |
| Citation | Analytica Chimica Acta, 2015, 885, 132?139 |
| DOI | https://doi.org/10.1016/j.aca.2015.04.037 |
A simple and sensitive surface enhanced Raman scattering (SERS)-based DNA sensor that utilizes the toehold-mediated DNA displacement reaction as a target-capturing scheme has been demonstrated. For a SERS substrate, Au?Ag bimetallic nanodendrites were electrochemically synthesized and used as a sensor platform. The incorporation of both Ag and Au was employed to simultaneously secure high sensitivity and stability of the substrate. An optimal composition of Ag and Au that satisfied these needs was determined. A double-strand composed of ‘a probe DNA (pDNA)’ complementary to ‘a target DNA (tDNA)’ and ‘an indicator DNA tagged with a Raman reporter (iDNA)’ was conjugated on the substrate. The conjugation made the reporter molecule close to the surface and induced generation of the Raman signal. The tDNA released the pre-hybridized iDNA from the pDNA via toehold-mediated displacement, and the displacement of the iDNA resulted in the decrease of Raman intensity. The variation of percent intensity change was sensitive and linear in the concentration range from 200 fM to 20 nM, and the achieved limit of detection (LOD) was 96.3 fM, superior to those reported in previous studies that adopted different signal taggings based on such as fluorescence and electrochemistry.
-
Read More
Tailoring Catalytic Activity of Pt Nanoparticles Encapsulated Inside Dendrimers by Tuning Nanoparticle Sizes with Subnanometer Accuracy for Sensitive Chemiluminescence-Based Analyses
Category2016 AuthorHyojung Lim, Youngwon Ju, and Joohoon Kim JournalAnal. Chem. CitationAnal. Chem. 2016, 88, 9, 4751?4758
-
Read More
Sensitive Electrochemical Penicillin Sensor Based on Screen-printed Carbon Electrode Modified with Dendrimer-encapsulated Pt Nanoparticles
Category2016 AuthorYoungwon Ju and Joohoon Kim JournalBull. Korean Chem. Soc. CitationBull. Korean Chem. Soc., 2016, 37, 397?400 -
Read More
Fluorescence Quenching of Dendrimer-Encapsulated CdS Quantum Dots for the Detection of H2O2
Category2016 AuthorHyojung Lim, Hai Dong Kim, Joohoon Kim JournalBull. Korean Chem. Soc. CitationBull. Korean Chem. Soc., 2016, 37, 254?257 -
Read More
Toehold-mediated DNA displacement-based surface-enhanced Raman scattering DNA sensor utilizing an Au?Ag bimetallic nanodendrite substrate
Category2015 AuthorSaetbyeol Kima , Tran Ngoc Huana , Joohoon Kimb , So Young Yoo, Hoeil Chung JournalAnalytica Chimica Acta CitationAnalytica Chimica Acta, 2015, 885, 132?139 -
Read More
Tailoring chemically converted graphenes using a water-soluble pyrene derivative with a zwitterionic arm for sensitive electrochemiluminescence-based analyses
Category2017 AuthorJihye Kwon, Seo Kyoung Park, Yongwoon Lee, Je Seung Lee and Joohoon Kim JournalBiosensors and Bioelectronics CitationBiosensors and Bioelectronics 87 2017 89?95
Designed by sketchbooks.co.kr / sketchbook5 board skin
Sketchbook5, 스케치북5
Sketchbook5, 스케치북5
Sketchbook5, 스케치북5
Sketchbook5, 스케치북5